thomsen disease การใช้

• This muscle weakness is not observed in people with Thomsen disease.
• Becker disease usually appears later in childhood than Thomsen disease, and causes more severe myotonia, muscle stiffness and transient weakness.
• Because several CLCN1 mutations can cause either Becker disease or Thomsen disease, doctors usually rely on characteristic signs and symptoms to distinguish the two forms of myotonia congenita.
• Mexiletine may also be of use in patients experiencing refractory pain and is also effective for treating muscle stiffness resulting from myotonic dystrophy ( Steinert's disease ) or nondystrophic myotonias such as myotonia congenita ( Thomsen disease ).